| Title | [Effect of botulinum toxin type A injection on hypertrophic scar in rabbit ear model] | | Author(s) | Wang L, Tai NZ, Fan ZH | | Institution | Plastic and Cosmetic Department, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China. | | Source | Zhonghua Zheng Xing Wai Ke Za Zhi 2009 Jul; 25(4):284-7. | | Abstract | OBJECTIVE: To investigate the effect of botulinum toxin type A (Botox A) injection on hypertrophic scar in rabbit ear model.
METHODS: The hypertrophic scar model was established in 16 Japanese rabbits' ears. These wounds were divided into two groups as group T (treated with Botox A, n = 48) and group S (not treated, n = 48). The wounds healing times and scar hypertrophy were observed with 8 specimen of normal skin at the rabbit ears as sham group B. HE stain was used to assess the hypertrophic index (HI). The expression of collagen I and III was tested by western-blot. The cell cycle of fibroblasts was studied by flow cytometry.
RESULTS: The HI was significantly lower in group T than in group S (P < 0.01). The expression of collagen I and III, as well as the ratio of I to III, was markedly stronger in group S than in group T (P < 0.01). Compared with group T, more fibroblasts were in G2-M in group S and fewer in G0-G1 (P < 0.05).
CONCLUSIONS: Local injection of Botox A can inhibit the formation of hypertrophic scar and the activity of fibroblasts in rabbit ear model. It can significantly decrease the expression of collagen I and III in hypertrophic scar, as well as the ratio of collagen I to III. It serves as the basis for the treatment of hypertrophic scar with Botox A. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19873722 |
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